Abstracts Book - IMRC 2018

• SB6-P087
DOUBLE NETWORK CHITOSAN-ALGINATE NANOPARTICLES FOR
DRUG DELIVERY: A DYNAMIC LIGHT SCATTERING STUDY
Egna Yaroslavh Rios Campos 1 , Eustolia Rodriguez Velazquez 2 , Manuel Alatorre Meda 1
1 Instituto Tecnológico de Tijuana, Centro de Graduados e Investigacion en Quimica, Mexico.
2 Universidad Autónoma de Baja California, Facultad de Odontologia-Tijuana, Mexico.
Thanks to their unique inner structure, double network nanoparticles (DN-NPs) are
envisaged as attractive carriers for a wide number of technological and biomedical
applications such as food industry, cosmetics, agriculture, and drug delivery, just to
cite a few. DN-NPs are entangled systems composed of two interpenetrated
polymeric networks where one of the networks is covalent in nature and the other
is ionic. This kind of structures are capable of encapsulating cargoes with virtually
any kind of structure and different degrees of water affinity, which are protected
the environment against degradation and can be released in a controlled way by
either simple diffusion or in response to selected stimuli. Recognizing their great
potential for tentative applications in the biomedical field, we herein explore the
synthesis and DLS characterization of DN-NPs produced natural polysaccharides
chitosan (CH) and alginate (ALG). Both polymers have been demonstrated in a great
deal of publications as non-toxic, biocompatible, and biodegradable, among
others. The double network structure was formed upon the direct ionic interaction
between positively charged methacrylated chitosan (referred to as CH-MA) and
negatively charged ALG, followed by the covalent crosslinking of the methacrylic
pendant groups of CH-MA driven by UV light irradiation. Two different
concentration regimes were explored. In the diluted regime (0.001 - 0.01 w/v%, CH
to ALG ratio of 1), the DN-NPs exhibited stable and compact sizes of around 300
nm, which are considered as optimal for applications in drug and gene delivery. By
contrast, at more concentrated regimes (0.1 w/v%, CH to ALG ratio of 1) the particles
proved to be bigger, exhibiting sizes in the order of microns. These results
demonstrate the DN-NPs produced CH and ALG, especially those produced at the
diluted regime, as optimal for tentative applications in the biomedical field.
Acknowledgment: E.Y. R.-C. thanks CONACyT (Mexico) for financial support
through PhD Grant No. 622036. This work was funded by CONACyT (Mexico)
through the Research Project PDCPN-2015-89.
Keywords: Double Network Nanoparticles, Drug Delivery, Dynamic Light Scattering
Presenting authors email: yrios09@icloud.com