Abstracts Book - IMRC 2018

• SB1-O022 Invited Talk
CYCLODEXTRIN-BASED SUPRAMOLECULAR STRCUTURES AS
DRUG DELIVERY NANOSYSTMES
Yareli Rojas Aguirre 1 , Patricia Guadarrama 1 , Manuel Alexis Torres Mena 1
1 Instituto de Investigaciones en Materiales, Polímeros, Mexico.
For the last decade, research in the drug delivery field was focused in the design
and development of nanosized drug delivery systems (nano-DDS). Advanced drug
delivery nanoplatforms displaying sophisticated structures and multiple functions
rapidly emerged. Despite the large number of publications, the translation of these
works to clinical applications has been scarce. It is time then to understand where
we are and what can we do to exploit the potential of nanosciences and transform
it into drug delivery technologies with tangible results. Some of the key aspects that
have to be address to overcome the drawbacks that the field is facing are: simple
structures obtained through feasible and scalable synthetic methods; the
“excipientability” (feasibility of a material to be proven as excipient) of the materials
comprising the structures; and the understanding of the interaction of the materials
with the biological barriers that the system will encounter until reaching the target.
This, combined with suitable chemical approaches can result in important progress.
For instance, DDS by supramolecular design is gaining great attention because,
through the control of dynamic and tunable non-covalent interactions, suitable
carriers can be engineered. Under this context, here we present the synthesis of
simple βcyclodextrin (βCD)-based supramolecular structures and the evaluation of
their potential as nano-DDS, which is done through the study of their
nanoproperties: size, topology and surface charge. The study of nanoproperties is
fundamental as they will determine the nano-DDS behavior in systemic circulation,
the extravasation and the ability to be internalized by specific cells. Thus, in this
work, the βCD derivatives are modified with materials that are currently used in the
pharmaceutical industry (i.e. polyethylenglycol) and are synthesized by click
chemistry (that has demonstrated to be highly quantitative for our systems). The
size, shape and charge are studied in media emulating physiological conditions.
Finally, all the information is integrated to determine the potential of the βCD
structures as nano-DDS.
Acknowledgment: Instituto de Investigaciones en Materiales, Proyecto 1306
Keywords: Nanomedicine, Cyclodextrin, Drug Delivery
Presenting authors email: yarelirojas@gmail.com