Abstracts Book - IMRC 2018

• SB2-P005
EFFECT OF MODIFICATION OF THE SURFACE OF MESOPOROUS
SILICA IN THE ADSORTION-DESORTION OF GRISEOFULVINE
Arlet Ariadne Rodriguez Castañeda 1 , Ma. del Carmen Salazar Hernández 1,2 , Mercedes Salazar
Hernández 3 , Raul Miranda Avilés 3 , Agustín Hilario Rocha Ramírez 4
1
Instituto Politécnico Nacional - IPN, Materiales y Termofluidos, Mexico. 2 Universidad de
Guanajuato, Minas, metalúrgica y geología, Mexico. 3 Universidad de Guanajuato, Minas,
Metalurgia y Geologia, Mexico. 4 Instituto Politécnico Nacional - IPN, Biología, Mexico.
Mesoporous silica (SM) is a material that has been used for the adsorption of
different materials since it has a hollow matrix that is capable of retaining all
types of molecules. This derives an interest in the pharmaceutical industry to
use mesoporous silica as an excipient of drugs, since it has been shown that it
is able to control the desorption of drugs, unlike traditional tablets. The control
in the desorption of the drugs adsorbed in the MS is due to the interactions that
the organic molecule has with the surface of the silica. In this work we study the
modification of the surface of silica with different functional groups that can
change the physicochemical properties regarding the adsorption and
desorption of a model drug that is Griseofulvin. The MS synthesis is performed
using the molecular sieve methodology. The obtained MS is modified with thiol
(-S) and octyl (-R) groups by post-synthesis; the of the functional groups to the
surface of the silica is observed by infrared spectroscopy and the percentage of
modification is quantified by gravimetry. Griseofulvin is adsorbed on silica and
the amount of drug adsorbed by gravimetry is quantified; the desorption
kinetics is studied at 37 o C at a pH of 7, which simulates the physiological
conditions of adsorption in the duodenum. As results, the effect of the
functional group on the pharmacokinetics of SiO2/Griseofulvin is demonstrated.
Acknowledgment:
The authors wish to acknowledge the financial support of the Instituto
Politécnico Nacional through grants SIP-20181395.
Keywords: Mesoporous silica, Drug deliver, Griseofulvin
Presenting authors email: arletrdz@hotmail.com