Abstracts Book - IMRC 2018

• SB6-P090
AMOXICILLIN CONTROLLED-RELEASE FROM POLYMERICS
HYDROGELS
Ana Valeria Torres Figueroa 1 , Cinthia Jhovanna Pérez Martínez 1 , Teresa del Castillo Castro 2 ,
Enrique Bolado Martínez 1 , María Alba Guadalupe Corella Madueño 1
1 Universidad de Sonora, Departamento de Ciencias Químico Biológicas, Mexico. 2 Universidad
de Sonora, Departamento de Investigación en Polímeros y Materiales, Mexico.
Hydrogels are water-compatible polymer networks which can increase their
volume several times without losing their shape. The applications for this type
of materials depend on their maximum swelling grade and mechanical
properties, such as: cross-linking porosity and density, their flexibility grade is
very similar to the natural tissue, which is why they constitute a very important
group in the pharmaceutical industry for biomedical applications, such as
controlled drug release systems. The advantages of these systems are possibility
of drug-administration in specific target organs, guarantee of treatment
continuity at night, stability of the drug and its optimal absorption by living
tissues, as well as the reduction of secondary effects. In this study we present
the evaluation of polyacrylamide / starch composed hydrogels synthesized at
different molar proportions (100/0, 90/10, 80/20, 70/30, 60/40, 50/50) as a
potential controlled release device of amoxicillin. The swelling capacity of the
compound hydrogels and the effect of the molar ratio between both polymers
on the release kinetics of the antibiotic under normal physiological conditions
of temperature and pH are evaluated in vitro.
Keywords: Amoxicillin controlled release, Poly(acrylamide), Starch
Presenting authors email: anavaleria.torresf@gmail.com