Abstracts Book - IMRC 2018

• SB5-O013
LIPOAMINO ACID: TWO-STEP SYNTHESIS OF THIOL-
FUNCTIONALIZED OLEIC ACID
María del Carmen Ley Flores 1 , Han Noé Umaña Kossio 1 , Marco Vizcarra 2 , Armando Lucero
Acuña 1,2 , Paul Zavala Rivera 1,2 , Anya Argüelles 2
1
Universidad de Sonora, Departamento de Ingeniería Química y Metalurgia, Mexico.
2 Universidad de Sonora, Posgrado en Nanotecnología, Mexico.
Since the discovery of spontaneous assemblies of thiols on the surface of gold
nanoparticles, the interest in thiol-terminated compounds has increased in
disciplines ranging electronics to biomedicine. Future progress on surface
modification relies on novel synthetic building blocks and methods that enable
substrate protection and added functionality, while diminishing costs and the
environmental impact. On this matter the thiol group of a terminal cysteine
residue can be exploited as the anchor group for the formation of a selfassembled
monolayers to gold metallic surfaces. The aim of this study was to
synthesize a thiol-modified fatty acid bioconjugate through the amide formation
between L-Cysteine and Oleic Acid using carbodiimide coupling reagents. The
process of making bioconjugates individual biomolecules results in the
formation of novel constructs that combine the properties of each of its
constituents, thus having characteristics not normally found among naturally
occurring substances while conserving their biocompatibility properties after its
degradation. The resulting lipoamino acid was structurally characterized using
(1)H NMR, FT-IR and mass spectroscopy.
Acknowledgment:
This research was supported by the Department of Chemical and Metallurgical
Engineering the Universidad de Sonora. We thank our colleagues the
Department of Nanotechnology and the Department of Polymers and Materials
Research, who provided reagents and analysis tools, as well as insight and
expertise that greatly assisted this research.
Keywords: Bioconjugation, Lipoamino Acid, Biomaterial
Presenting authors email: maricarmenleyf@gmail.com