Abstracts Book - IMRC 2018

• SB6-O016
SYNTHESIS, STUDY AND CHARACTERIZATION OF
HYDROXYAPATITE FOR BONE GROWTH ACCELERATION UNDER
ELECTRIC FIELDS
Ricardo Perez Solis 1 , María Eugenia Mendoza 1 , Abel Moreno Carcamo 2
1 Benemerita Universidad Autonoma de Puebla, Physics Institute, Mexico. 2 Instituto de Quimica
UNAM, Departamento Química de Biomacromoléculas, Mexico.
Biomaterials are intended to replace or regenerate tissues within the living
organism; in this classification, the biocomposites are used to fabricate implants
that also are bioactive, in other words, they form a strong implant-tissue
interfacial bond, being bioabsorbable or biodegradable. Natural bone is wellknown
to consist of 60% - 70 wt% carbonate hydroxyapatite (HA)
[Ca10(PO4)6(OH)2], 20% - 30 wt % organic matrix and 10% water. Crystallographic
and chemical studies had shown that synthetic HA is similar to the natural
inorganic component found in the bone matrix and teeth; because of this close
similarity an extensive research effort to employ synthetic HA as a bone
substitute and/or replacement in several biomedical application has been made.
Piezoelectric properties of the HA matrix have been improved as a compound
with organic or inorganic materials which provide elasticity to the rigid matrix
which increase bone growth. The synthetic sample studied was prepared via solgel
technique under the influence of ultrasonic radiation. During the process,
the ratio Ca/P set at 1.67 and the pH was maintained at 9. Due to the close
similarity between a monoclinic and hexagonal phase of the HA, the importance
of stabilizing the monoclinic phase at room temperature with ultrasound
irradiation  is relevant because of the advantages of using the piezoelectric
properties of the monoclinic phase, in new medical rehabilitation therapies. To
distinguish the phases of HA, the sample was also examined using piezoelectric
force microscopy (PFM) to measure the piezoelectric coefficient d33 and XRD
diffraction using synchrotron light to determine the crystallographic phases. The
combination of the study by XRD and PFM has allowed corroborate the
quantification of the monoclinic phase. Although the structural differences
between monoclinic and hexagonal HA are very small, they are sufficient to
exert a strong impact on some of their physicochemical properties. A bone
substitute material should consider this structure-property relationship.
References
V.P. Orlovskii, V.S. Komlev, and S.M. Barinov, Hydroxyapatite and
Hydroxyapatite-based Ceramics•, Inorg Mater+ Vol.38, 10, pp. 973-984 (2002)