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Abstracts Book - IMRC 2018

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• SB2-P009<br />

NANOCELLULOSE TEMPLATED GROWTH OF ULTRA-SMALL<br />

BISMUTH NANOPARTICLES FOR ENHANCED RADIATION<br />

THERAPY<br />

Qingxuan Li 1 , Li Jiao 1 , Ming Su 1<br />

1 Northeastern University, Chemical Engineering, United States.<br />

An unmet need in nanomedicine is to prepare biocompatible and renal<br />

clearable nanoparticles by controlling the diameter, composition and surface<br />

property of nanoparticles. This paper reports cellulose nanofibers templated<br />

synthesis of ultra-small bismuth nanoparticles, and their uses in enhanced X-ray<br />

radiation therapy. The interstitial spaces between adjacent fibers are the<br />

adsorption sites of bismuth ions and also stabilize nanoparticles made chemical<br />

reduction. The sizes of nanoparticles are tailored in 2-10 nm range using<br />

cellulose nanofibers with various amounts of carboxyl group. In vitro<br />

cytotoxicity, reactive oxygen species (ROS) and in vivo animal tests with tumorbearing<br />

mice of cellulose nanofibers-templated bismuth nanoparticles are<br />

studied to enhance X-ray radiation therapy. Bismuth nanoparticles show strong<br />

X-ray attenuation ability, concentration-dependent cytotoxicity and high level<br />

production of ROS upon X-ray exposure, which is consistent with enhanced<br />

cellular damage and retarded growth of tumor in animal.<br />

Acknowledgment:<br />

This project was supported by a Director’s New Innovator Award National<br />

Institute of Health (1DP2EB016572).<br />

Keywords: Cellulose nanofibers, Bismuth nanoparticles, Radiation therapy<br />

Presenting authors email: li.qi@husky.neu.edu

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