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Mathematical Model of Affinity-based Drug Delivery System
by Using Partial Differential Equation
Tan Li Chin
Supervisor: Dr. Shalela Binti Mohd. Mahali
Bachelor of Science (Computional Mathematics)
School of Informatics and Applied Mathematics
Affinity-based drug delivery system have been developed to overcome the limitation of
unmodified hydrogel. An example of an affinity is provided by the heparin-based but is
not optimal for controlled released growth factors that have weak affinity for heparin.
Thus, a peptide-based delivery system of mathematical model should be developed to
represent how the affinity of a peptide can modulate the release of nerve growth factor
(NGF). This study aims to develop a mathematical model to represent a peptide-based
affinity drug delivery system and to evaluate the NGF release profiles based on the
theoretical data. An explicit finite difference scheme is used to numerically integrate the
mathematical model of peptide-based drug delivery system. At the end of the study, the
graphs of the predicted fraction of total growth factor release and it has shown that the
more the concentration of the peptide, the slower the fraction of growth factor released.
1010 | UMT UNDERGRADUATE RESEARCH DAY 2018