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Screening Of Advanced Glycation End Products (Ages) Inhbitory<br />

Activities in Traditional Herbal Medicines<br />

Heah Lee Hua<br />

Supervisor: Prof Fadzilah Adibah Binti Abd Majid<br />

Bachelor of Applied Science<br />

(Biodiversity Conservation and Management)<br />

School of Marine and Environmental Sciences<br />

Universiti Malaysia Terengganu<br />

Advanced glycation end products (AGEs) is a non-enzymatic reaction between<br />

proteins with reducing sugar. This reaction can cause the development of<br />

diseases such as diabetic, cardiovascular diseases and Alzheimer diseases.<br />

Herbal medicines play a crucial role in the development in modern human life<br />

and have a significant effect on treating diseases. The aim of this study is to<br />

determine antiglycation potential of traditional herbal medicine (Aidecine,<br />

Synacinn, Sanativ and Jd-10) at multiple stages. A vitro model of glycation<br />

which is BSA-glucose was used in this experiment. The experiment was carried<br />

by out by determined level of fructosamine, protein carbonyl and AGEs for 30<br />

days. The result showed that these traditional herbal medicines have significant<br />

inhibition effect at multiple stages. In conclusion, these four herbal medicine<br />

posses fructosamine, protein carbonyl and AGEs inhibitory effect which can help<br />

to decrease or control the development of diabetic complication.<br />

1690 | UMT UNDERGRADUATE RESEARCH DAY 2018

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