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Mathematical Model of Drug Dissolution of Carbidopa & Levodopa Tablets<br />

Ahmad Murshidi Bin Mohd Zulkifli<br />

Supervisor: Dr. Shalela Binti Mohd Mahali<br />

Bachelor of Science (Computational Mathematics)<br />

School of Informatics and Applied Mathematics<br />

This research is mainly about mathematical analysis on drug dissolution of Carbidopa and<br />

Levodopa tablets. Drug dissolution is a process which a solid drug enters in to a solution.<br />

In this research, a model that consider the physical changes to the drugs is acknowledged<br />

and studied, aimed to calculate in-vitro drug release of a spherical drug with the<br />

assumptions that the drug still maintained its spherical shape as it dissolved. At the same<br />

time, real data of the same drug dissolutions from in-vivo testing is recorded for<br />

reference. The first objective is to evaluate the unknown parameters of Carbidopa and<br />

Levodopa drug releases in Hixson-Crowell model based on real in-vitro laboratory data.<br />

The second is to manually determine the drug dissolution of both tablets. At the end of<br />

this research, Hixson-Crowell model can be considered to calculate the real-life drug<br />

dissolution as the data of both drugs releases calculated using the model are close to the<br />

real in-vivo data.<br />

911 | UMT UNDERGRADUATE RESEARCH DAY 2018

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