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Modeling the Concentration of Tirapazamine in the Blood
Vessels by using 2-Compartment Model
Nurul Nadia Ezaty Binti Mohamad Asri
Supervisor: Puan Siti Madhihah Binti Abdul Malik
Bachelor of Science (Financial Mathematics)
School of Informatics and Applied Mathematics
The increase in the number of Malaysians suffering from tumor caused another treatment
method to be sought to cure the illness. A new alternative method has been introduced
which is the use of a drug named Tirapazamine. The combination of chemotherapy,
radiotherapy, and Tirapazamine can kill more tumor cells effectively because
Tirapazamine is able to increase the sensitivity of tumor cells to radiotherapy. In this
study, a patch that contains Tirapazamine has been used. Therefore, a two-compartment
model has been developed to study the change in the concentration of Tirapazamine on
the patch and in the bloodstream. This model has been solved by using the separation of
variable and integrating factor method. The result shows that the concentration of
Tirapazamine has decreased over time on the patch. However, in the bloodstream, the
concentration of Tirapazamine has increased at first and then, decreased over time.
878 | UMT UNDERGRADUATE RESEARCH DAY 2018