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Hydrogel Drug Delivery: Diffusion Models<br />

Nurul Atiqah Binti Muhammad Amin<br />

Supervisor: Dr. Shalela Binti Mohd. Mahali<br />

Bachelor of Science (Computational Mathematics)<br />

School of Informatics and Applied Mathematics<br />

Hydrogel is three-dimensional structure that consists of cross-linked polymer that allow<br />

the polymer structure to swell when it is imbibe with fluid. In this research, we will<br />

elucidate the drug release characteristics of diffusion and swelling system. Hydrogel drug<br />

delivery involve in diffusion and swelling controlled system. We will focus on the solute<br />

release characteristics of diffusion and swelling system. This model shows the drug<br />

release in one dimensional. Diffusion model can be solve using advection-diffusion<br />

equation. The equation cannot be solved analytically because of the presence of an<br />

advection term and the moving boundary of hydrogel. Therefore, the Landau<br />

transformation is used to simplify the problem. Three types of growth function that we<br />

studied were linear, exponential and logistic growth. At the end of this research, we will<br />

obtain the results using MATLAB software to compare the analytical results with numerical<br />

simulations.<br />

990 | UMT UNDERGRADUATE RESEARCH DAY 2018

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