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Potential Inhibitor to Abnormal Involuntary Movement Disorder:
Dimethoxy-Terphenyl and 3-(4-Methoxy-Phenyl)-Dibenzofuran Targeting
Monoamine Oxidase B
Goh Meng Shien
Supervisor: Dr. Muhamad Fairus Bin Hassim
Co-supervisor: Dr. Fatimah Binti Hashim
Bachelor of Science (Biological Sciences)
School of Fundamental Science
Abnormal involuntary movements (AIM) disorder is symptom of Parkinson and seizure.
Usually associated with false signalling of monoamine oxidase B (MAOB) associated
pathway in synapse. Our study identifies new terphenyl-based compounds that
interact with MOAB. Cytotoxicity of dimethoxy-terphenyl (14MP) and 3-(4-Methoxyphenyl)-dibenzofuran
(FD1) were assessed. Through computational approach, we
identified potential proteins that interacted with the compounds and characterized the
type of interaction. Cytotoxic assessment using MTT shows minimal cytotoxicity to
NIH-3T3 and RAW264.7, however 14MP is more toxic than FD1. Homologous database
screening to find proteins targeted by these compounds shows that 14MP has the
highest probability to interact with MAOB and amyloid precursor-like proteins (APLPs).
While for FD1 are inducible nitric oxide synthase (P35228) and MAOB. However,
further molecular docking analysis shows that MAOB has the highest binding affinity
with 14MP and FD1. Thus, indicate potential inhibitor for MAOB from false breaking
down dopamine hence causing AIM.
360 | U M T U N D E R G R A D U A T E R E S E A R C H D A Y 2018