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In Vivo Evaluation of Marphysa Moribidii Extracts on Wound Healing
Logeiswariy Perumal
Supervisor: Assoc. Prof Dr. Wan Iryani Wan Ismail
Co-Supervisor: Dr. Suvik Assaw
Bachelor of Science (Biological Sciences)
School of Fundamental Science
Acute wound cases are increasing every year. Current treatment in acute wound
healing has many adverse impacts and looking for alternative. Marphysa moribidii; a
local polychaete has a promising potential as a new option in wound healing because
of its regenerative capability. Hence, this study aimed to determine the effectiveness
of aqueous polychaete extract, M. moribidii in wound healing treatment. Collected
samples were finely pulverised and lyophilized by freeze dryer to form a powdery-form
extract prior to prepare in three different concentrations (0.3%, 1.0% and 2.0%). The
aqueous extract emulsifying ointment of M. moribidii was applied on rat model. Wound
contraction and histopathological analysis were taken to determine its effectiveness in
wound healing. Results demonstrated that aqueous M. moribidii extracts showed rapid
wound healing after applied on rats even at lower concentration (0.3%) compared to
controls at 0.4% concentration i.e., commercial antiseptics; acriflavin and gamat
ointment (sea cucumber extract).
380 | U M T U N D E R G R A D U A T E R E S E A R C H D A Y 2018