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Effect of Acetaminophen on Physicals and Compression Behaviors of
Kelcogel as Wound Materials
Nor Faten Kartini Binti Ramli
Supervisor: Assoc. Prof Dr. Khairul Anuar Bin Mat Amin
Bachelor of Science (Chemical Sciences)
School of Fundamental Science
This study investigates the compression performances, swelling and Water Vapour
Transmission Rates (WVTRs) of Kelcogel at different thickness. The Kelcogel at 2 mm
thickness (KEL-2) shows the optimum compression strength and swelling ratio at 155
± 33 kPa and 99 ± 5%, respectively compared to other samples. KEL-2 hydrogel films
were incorporated with acetaminophen and the properties were examined. The
compression strength of KEL-2 with addition of 30% w/w acetaminophen (KEL-A30)
was increased to 427 ± 47 kPa, an increment of almost 3-fold than KEL-2 film. The
swelling ratios of the KEL-A30 hydrogel films were increased to 108 ± 7%. The water
vapour transmission rate (WVTR) of the hydrogel films were in the range of 2329 -
4699 g m -2 d -1 . The addition of acetaminophen improved the strength and swelling
ratios of the Kelcogel and promising to be applied as dressing materials.
428 | U M T U N D E R G R A D U A T E R E S E A R C H D A Y 2018