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Controlled Drug Release for Cardiovascular Stents
Nur Atiqah Binti Yusoff
Supervisor: Dr. Shalela Binti Mohd Mahali
Bachelor of Science (Financial Mathematics)
School of Informatics and Applied Mathematics
Drug-eluting stent (DES) have greatly transformed in the field of interventional
cardiology. Drug-eluting stents has dramatically reduced restenosis and request for reintervention.
Furthermore, drug-eluting stent is a metallic prosthesis implanted into the
arterial wall and coated with a layer of biocompatible polymeric gel that encapsulates a
therapeutic drug. In this paper, we are interested in the mechanism of drug elution into
the arterial tissue as stent acts as a source of drug which is transport from coating of
stent to arterial wall. An analytical solution to the model is derived and a formula drug
mass (per unit area) as function of time in both coating of stent and arterial wall is
obtained. The effectiveness of the method is well demonstrated by the numerical results.
Besides, the model is used to determine the concentration of drug at both coating and
arterial wall.
855 | UMT UNDERGRADUATE RESEARCH DAY 2018