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Synthesis and Characterization of Alkoxy Substituted Chalcone Derivatives
as Potential Treatment for Breast Cancer (MCF-7) Cells
Mas Binti Mohammed
Supervisor: Assoc. Prof. Dr. Wan Mohd Khairul Wan Mohamed Zin
Co. Supervisor: Dr. Fatimah Binti Hashim
Bachelor of Science (Chemical Sciences)
School of Fundamental Science
Breast cancer is the major cause of cancer related to death among females worldwide.
However, chalcone derivatives are have been identified to become the potential to
treat breast cancer cells. In this study, three new alkoxy substituted chalcone
derivatives (2a-2c) featuring general formula of X(C6H4)C3H2O(C6H4)Y which X
represent NO2, CN, and CF3 and Y as hexyloxy group have been successfully designed,
prepared, characterized and evaluated the biological activities towards breast cancer
cells (MCF-7). They were used to investigate the cytotoxicity effect on MCF-7 by
evaluated MTT assay to determine the IC50 values. ELISA plate reader was used to
determine the IC50 values. The cytotoxicity of the compounds were evaluated based
on dose-response on MCF-7 cells which exhibited all of the compounds were in active
range with IC50 values 31.82, 41.05 and 24.38 g/mL respectively. In conclusion, the
compounds have potential to establish as new anticancer agents in further research.
417 | U M T U N D E R G R A D U A T E R E S E A R C H D A Y 2018