merged

Green Synthesis of Benzothiazole derivatives assisted by Cetrimonium
Bromide
Lim Ban Soon
Supervisor: Dr. Chia Poh Wai
Bachelor of Science (Analytical and Environmental Chemistry)
School of Marine and Environmental Science
Universiti Malaysia Terengganu
In this research work, an efficient solvent- and metal-free catalytic system has been
developed for the synthesis of benzothiazole derivatives via a one-pot threecomponent
cyclocondensation of aromatic aldehyde derivatives 28, ethyl acetoacetate
46, and 2-aminobenzothiazole 14. Under this protocol, cetrimonium bromide
surfactant was employed in the multi-component reaction for benzothiazole synthesis
procedure. This environmental-friendly catalytic system had successfully led to the
synthesis of the desired benzothiazole derivatives (47-51) in excellent to moderate
yield under solvent-free conditions at 100 ̊ C. In addition, benzothiazole compound 47
were efficiently synthesized in a more environmental-friendly and non-tedious protocol
with reference to the simple procedure and shorter reaction time as compared to the
synthetic protocol without employment of the cetrimonium bromide surfactant. In
future work, cetrimonium bromide surfactant can be utilized as an efficient catalyst in
the preparation of benzothiazole derivatives by using other reagent instead of 2-
aminobenzothiazole to react with the aromatic aldehyde.
1947 | UMT UNDERGRADUATE RESEARCH DAY 2018