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Synthesis and Characterization of Carbonyl Thiourea Derivatives
Siti Rahimah Binti Abd Rahman
Supervisor: Prof Madya Dr. Mohd Sukeri Bin Mohd Yusof
Bachelor of Science (Chemical Sciences)
School Of Fundamental Science
Four new carbonyl thiourea derivatives have been synthesized by refluxing mixture of
acyl chloride, isothiocyanate intermediates, and aromatic amine in acetone. The four
structures of the synthesized compounds were characterized by Fourier Transform
Infrared (FT-IR) spectroscopy, 1 H and 13 C Nuclear Magnetic Resonance (NMR)
spectroscopy, CHNS Element Analyzer and Mass Spectroscopy. The infrared spectra
of these compound showed four significant stretching vibration of v(N-H), v(C=O),
v(C-N), and v(C=S) at 3155 - 3184 cm -1 , 1689.06- 1698.35 cm -1 , 1369.14-1380.30
cm -1 and 759.24-773.60 cm -1 , respectively. In the 1 H spectra, the signal of δH(N1) and
δH(N2) presence at around δH 11-12 ppm. The 13 C NMR spectra showed signal of
carbonyl and thione carbon can clearly observed at δc 173-179 ppm and 180-181
ppm, respectively and it is proved by Mass spectroscopy. From the CHNS element
analysis, these four new thiourea are revealed good agreement with slightly small
difference value compared to theoretical value.
458 | U M T U N D E R G R A D U A T E R E S E A R C H D A Y 2018