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THE EFFECT OF NAMALYCASTIS SP. ON BREAST CANCER (MCF-7)
MIGRATION
Rosmah Suhaila binti Hamdan
Supervisor: Dr. Thilahgavani Nagappan
CO-Supervisor: Dr. Maziah Binti Mohd Ghazaly
Bachelor of Applied Science
(Biodiversity Conservation and Management)
School Marine and Environmental Sciences
Breast cancer is the most common cancer on rise globally and resistance toward
drugs is preventing the inhibition of this aggressive cancer cells. Recently,
marine organisms, which is Namalycastis sp. were assessed as a potential
resource for drug recovery research. Based on previous studies, it has shown
the regeneration capabilities in marine worms may work as potential inhibitor
in multidrug resistant cancer cell. Therefore, our aim is to determine the
cytotoxicity level of Namalycastis sp. on MCF-7 cells growth and to observe the
effect of Namalycastis sp. crude extract on MCF-7 cell migration. In this study,
MCF-7 were treated with Namalycastis sp. by using MTT assay and migration
assay. Based on this assays, it was found that Namalycastis sp. could slow
down the proliferation of MCF-7 cell. Further research on the principle active
components of crude extract of Namalycastis sp. will leads to development of
drug to treat breast cancer (MCF-
7).
1761 | UMT UNDERGRADUATE RESEARCH DAY 2018