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The Effects of Etlingera corneri Crude Extract on Breast Cancer Cell
Growth and Proliferations
Nurul Athifah binti Din
Supervisor: Dr. Lee Gaik Ee
Bachelor in Applied Science
(Biodiversity Conservation and Management)
School of Marine and Environmental Sciences
Breast cancer is the most common cancer that effects both men and women
worldwide. This occurs as the breast cancer cells are resistant to the current
drugs. Etlingera corneri is a rare species and was hardly found in the wild. This
study focused on the cytotoxicity of E. corneri crude extracts and the reactive
oxygen species (ROS) level in the breast cancer cells (MCF-7) when treated
with the crude extract. Cytotoxic evaluation was carried out with the plant
extracts (0-1000µg/mL) using 24-hours MTT assay. The exposure of the extract
reduced the cell viability of MCF-7. The ROS level was determined using
dihydroethidium (DHE) staining and the result also shows that the ROS level in
the cells reduced when treated with the extracts. In conclusion, the extract of
E. corneri has potential in treating cancer. Further study should be carried out
to introduce the benefit of the plant to the world.
1750 | UMT UNDERGRADUATE RESEARCH DAY 2018