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Synthesis of Coumaric Acid Derivatives via Dicyclohexylcarbodiimide<br />

(DCC) Coupling Reaction<br />

Gloria Bangie Anak Bandar<br />

Dr. Asnuzilawati Binti Asari<br />

Bachelor of Science (Chemical Sciences)<br />

School of Fundamental Science<br />

Coumaric acid is a natural compound isolated from cereal. It can also be obtained<br />

from Perkin Reaction by reacting cinammic acid with acid anhydride. Coumaric acid<br />

possesses various biological activities including anti-atherosclerosis, anti-tumor,<br />

antioxidant, and anti-inflammatory. The aim of the study is to synthesis pentyl<br />

coumarate by coupling reaction. In this study, coumaric acid was reacted with 1-<br />

pentanol in the presence of DMAP as catalyst by employing Dicyclohexylcarbodiimide<br />

(DCC) coupling reaction. From the result, synthesis via DCC coupling reaction at 0°C<br />

is better than at room temperature because ester product with less impurities was<br />

obtained. In conclusion, pure ester product was not successfully obtained because of<br />

the presence of by product Dicyclohexylurea (DCU).<br />

412 | U M T U N D E R G R A D U A T E R E S E A R C H D A Y 2018

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