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Synthesis, Characterized and Antibacterial Screening of Ni(II) Complex
with N2O2 Schiff Base Ligand
Nor Syuhadaa binti Che Abdullah
Supervisor: Dr. Siti Kamilah binti Che Soh
Co-Supervisor: Dr. Suvik A/L Assaw
Bachelor of Science (Analytical and Environmental Chemistry)
School of Marine and Environmental Science
Universiti Malaysia Terengganu
A Schiff base ligand namely N,N’-bis(2-hydroxyacetophenone)propane-1,3-diamine
was synthesized by condensation reaction of 1,3 diaminopropane and 2-
hydroxyacetophenone. Then the corresponding metal complex was formed through
the complexation of nickel(II) acetate with the synthesized ligand using 1:1
equivmolar ratio. Both synthesized compounds were spectroscopilly characterized by
FT-IR, NMR, UV–Vis and CHN analysis. Then the compounds were screened to the
antibacterial activities using six selected species from human pathogenic bacteria
comprise of Gram-positive such as Staphylococcus epidermidis, Bacillus subtilis and
Staphylococcus aureus and Gram-negative like Vibrio cholera, Enterobacter cloacae
and Escherichia coli. Well-diffusion assay method was used to determine which
synthesized compounds were the most effective in inhibiting bacterial growth. In
addition, the antibacterial investigations showed that the complex was more
biologically active compound compared to the parent Schiff base ligand against all the
tested pathogenic species. It revealed that the performance of antibacterial activity
was dependent on the molecular structure of the compound.
1954 | UMT UNDERGRADUATE RESEARCH DAY 2018